Abstract Dr. Loutsch
Phenotypic Signature of Osteosarcoma
Jeanette Loutsch, PhD
Abstract
Osteosarcoma (OS) is a rare tumor of the bone and soft
tissue found usually in adolescent children and even rarer in adults. This tumor
has a poor prognosis when metastasis is present at time of diagnosis. It is the
goal of this research proposal to investigate the phenotypic signature of OS in
adult and adolescent onset. This will be accomplished by performing cDNA
microarray analysis of tumors at the UAMS tissue bank with validation of the
genes that were either expressed in at a higher or lower level than normal bone
tissue. The validation of the gene product will consist of immunohistochemical
analysis of tumor sections and cultured OS cells, Saos2 with additional RT-PCR
of the genes expressed in the Saos2 cell line. These preliminary studies will
aid in the understanding of the tumor progression.
Updated 07/31/2006
The Arkansas INBRE is Supported by a grant from the
National Institutes of Health
and the
National Center
for Research Resources (P20 RR-16460).
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